Classical biological pest control is the introduction of natural enemies to a new locale where they did not originate or do not occur naturally. This is usually done by government authorities. In many instances the complex of natural enemies associated with an insect pest may be inadequate. This is especially evident when an insect pest is accidentally introduced into a new geographic area without its associated natural enemies. These introduced pests are referred to as exotic pests and comprise about 40% of the insect pests in the United States. Examples of introduced vegetable pests include the European corn borer, one of the most destructive insects in North America. To obtain the needed natural enemies, scientists turned to classical biological control. This is the practice of importing, and releasing for establishment, natural enemies to control an introduced (exotic) pest, although it is also practiced against native insect pests. The first step in the process is to determine the origin of the introduced pest and then collect appropriate natural enemies associated with the pest or closely related species. The natural enemy is then passed through a rigorous quarantine process, to ensure that no unwanted organisms (such as hyperparasitoids) are introduced, then they are mass produced, and released. Follow-up studies are conducted to determine if the natural enemy becomes successfully established at the site of release, and to assess the long-term benefit of its presence.

There are many examples of successful classical biological pest control programs. One of the earliest successes was with the cottony cushion scale, a pest that was devastating the California citrus industry in the late 1800s. A predatory insect, the vedalia beetle, and a parasitoid fly were introduced from Australia. Within a few years the cottony cushion scale was completely controlled by these introduced natural enemies. Damage from the Alfalfa weevil, a serious introduced pest of forage, was substantially reduced by the introduction of several natural enemies. About 20 years after their introduction, the population of weevils, in the alfalfa area treated for alfalfa weevil in the northeastern United States, was reduced by 75 percent. A small wasp, Trichogramma ostriniae, introduced from China to help control the European corn borer, is a recent example of a long history of classical biological control efforts for this major pest. Many classical biological control programs for insect pests and weeds are under way across the United States and Canada. The population of Levuana Moth, a serious coconut pest in Fiji was brought under control by a classical biological control program in the 1920s. Classical biological control is long lasting and inexpensive. Other than the initial costs of collection, importation, and rearing, little expense is incurred. When a natural enemy is successfully established it rarely requires additional input and it continues to kill the pest with no direct help from humans and at no cost. Unfortunately, classical biological pest control does not always work. It is usually most effective against exotic pests and less so against native insect pests. The reasons for failure are often not known, but may include the release of too few individuals, poor adaptation of the natural enemy to environmental conditions at the release location, and lack of synchrony between the life cycle of the natural enemy and host pest.