Question
I hae 2 Angel Trumpet bushes, they are over taking the space, Can I cut them back?
How often can I cut them back?  and
Is there any
special pruning instructions?

Answer
Cat,
Angels Trumpet (Datura inoxia) has many names- Jimsonweed, Devils Trumpet or Deadly Nightshade. It can be cut back at any time of the year if they are healthy and kept well watered. Removing the burrs will force the plants to flower longer (and stop this weed from spreading where you do not want it to be..
There are no special pruning requirements. Make sre your pruners are sharp and cut back to a lateral for best healing and to maintain good overall health.