Question
I have noticed dozens of yellow jackets coming in and out of a hole about 3 ft above ground level in my white oak tree. I also have a groundhog living under the same oak tree, with his entrance hole below the area the bees are invading. Other silver-dollar sized areas of bark on the tree are gone.  Is this merely slime flux, that I can ignore? What else should I consider? This tree is estimated to be 350 years old and I would hate to loose it.

Answer
If the yellow jackets are actually going in a hole in the trunk this is a nest. IF they are just going to wet areas on the bark they are feeding on the sap from slim flux.

IF it is a nest you can try killing them your self OR call a experminator--I would suggest the exterminator. They insect can sting and attack in numbers. A treatment would have to be sprayed into the hole and then the hole sealed. Best to let a professional do this and get strung.

Wetwood and slime flux are poorly understood tree disease problems. Wetwood is an internal bacterial infection in the wood of host trees. Slime flux is an external bleeding of sap typically associated with such infections.  Concern is sometimes justified as wetwood and slime flux can cause noteworthy debilitating effects on infected trees including some dieback or decline, and an inability for wounds or pruning scars to form callus tissue for healing.
Recognition: Wetwood and slime flux are most often recognized by the oozing, bleeding, or fluxing of sap from bark fissures, pruning scars or wounds on the stems or branches of infected trees. Fluxing often occurs in branch crotches resulting from the tearing of tissues at these junctures by excessive branch weight, wind, etc. The oozing sap is usually dark brown, frothy or slimy and foul smelling soon after it is exposed to the air due to the activity of certain bacteria, yeast and other fungi by which it is rapidly colonized - hence the name slime flux. Slime flux, when profuse, characteristically flows downward from its points of emergence, and upon drying leaves a light gray to whitish incrustation on the surface of the bark. Due to its oftentimes highly alkaline nature, slime flux frequently results in the death of turf, shrubs, and plants on which it drips beneath infected trees.

Internally, wetwood is typically characterized by dark brown discolored wood which appears circular in cross section and wet or water-soaked. This wet wood is also characteristically malodorous, much like the normally associated slime flux.

Infection Biology:
The bacteria associated with wetwood and slime flux are common soil and water inhabitants. These organisms presumably gain entry into susceptible stem-wood tissues through wounds or pruning scars via certain insects, pruning tools, birds, and wind. Additional infections appear to be possible through direct root penetration or colonization of root wounds. Once established within the host the bacteria multiply and colonize the tree's central heartwood core. To a limited extent, the bacteria may also colonize portions of the outer, sapwood tissues. The metabolic activities of the bacteria within infected wood tissues generate a variety of gases, predominantly methane, nitrogen, and carbon dioxide. These gases, when confined within the wood tissues, produce unusually high pressures which force the sap outward through wounds and branch stubs giving rise to the readily identifiable, external slime flux.  

There is no known effective control for slime flux. Inserting drain tubes around the affected area is no longer recommended. It may only help spread bacterial population within the tree and create wounds conducive to the entry of wood decaying fungi. Preventative measures such as avoiding moisture stress, proper pruning and adequate fertilization may help invigorate trees. I would fertilize the tree with 10-10-10 fertilizer at the rate of 1 lb per inch of trunk diameter scattered around the tree and watered in good. Apply the fertilizer just before a rain storm and you will not have to water it in.

As far as the ground hog I am an expert on animal control so can not comment on this.